Multiple Molecular Penumbras after Focal Cerebral Ischemia
نویسندگان
چکیده
منابع مشابه
Functional differentiation of multiple perilesional zones after focal cerebral ischemia.
Transient and permanent focal cerebral ischemia results in a series of typical pathophysiologic events. These consequences evolve in time and space and are not limited to the lesion itself, but they can be observed in perilesional (penumbra) and widespread ipsi- and sometimes contralateral remote areas (diaschisis). The extent of these areas is variable depending on factors such as the type of ...
متن کاملFocal Cerebral Ischemia
We investigated the temporal threshold for focal cerebral infarction in the spontaneously hypertensive rat The right middle cerebral artery and common carotid artery were occluded for 0,1 ,2 ,3 ,4 , or 24 hours, and all the animals were sacrificed 24 hours after the onset of ischemia. Cortical infarct volumes and edema volumes were quantified in serial frozen sections of hematoxylin and eosin-s...
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Introduction: Cerebral ischemia is one of the most common causes of death in human populations in the industrial communities. The need for animal models is inevitable to study the pathophysiology and treatment of cerebral ischemia in human. The current study aimed at evaluating the strengths and weaknesses of different techniques used to create ischemia in previous studies and optimizing the tr...
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BACKGROUND AND PURPOSE This article addresses how neuroplastic changes are initiated after an ischemic stroke. METHODS A focal cerebral ischemia was photochemically induced on the primary somatosensory cortex of rats, and in vivo electrophysiological recordings were performed on the peri-infarct cortex before and from 1 to 6 hours after the infarction. RESULTS Paired-pulse analysis of evoke...
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Vascular endothelial growth factor (VEGF) is an angiogenic protein with therapeutic potential in ischemic disorders, including stroke. VEGF confers neuroprotection and promotes neurogenesis and cerebral angiogenesis, but the manner in which these effects may interact in the ischemic brain is poorly understood. We produced focal cerebral ischemia by middle cerebral artery occlusion for 90 minute...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 2000
ISSN: 0271-678X,1559-7016
DOI: 10.1097/00004647-200007000-00001